Synthesis and Antimicrobial Activity of Some Piperid-4-one Derivatives against Bacterial Strains

A novel compound 2-(2-ethoxyphenyl)-5-hydroxy-1-(2-hydroxyethyl)-5-methyl piperidin-4-one (II) has been synthesized by a previously well-known reaction between (E)-3-(2-ethoxyphenyl)-1-(2-methyloxiran-2-yl)prop-2-en-1-one (I) and ethanol amine. The was used to synthesize (Z)-2-((2S,5S)-2-(2-ethoxyphenyl)-5-hydroxy-1-(2-hydroxyethyl)-5-methylpiperidin-4-ylidene)hydrazine-1-carbothioamide (III) through con-den¬sation with thiosemicarbazide in acidic medium. Structures were confirmed spectral data (IR,1H-NMR LC-MS). Potential antimicrobial efficiency of the newly derivatives studied against Gram-positive bacterial strain (Staphylococcus aureus) Gram-negative (Enterobacter sp.) applying agar dilution method. results showed that higher activity than (II).